An efficient and green synthesis of some novel benzodiazepine derivatives and their antimicrobial screening

In present communication a novel series of benzodiazepine derivatives were synthesized from α, β-unsaturated ketones and evaluated for their antimicrobial activities. The α, β-unsaturated ketones were prepared by ClaisenSchimidt Condensation of Indan-1-one with different aldehydes in presence bleaching earth clay and PEG400 as Greener reaction solvent. A novel benzodiazepine derivatives were synthesized by the reaction of α,βunsaturated ketones with o-phenylenediamine in Polyethylene glycol (PEG-400) and few drop of acetic acid. The chemical structures of the newly synthesized compounds were confirmed by IR, H NMR and Mass spectral data. All compounds of the series have been screened for their antimicrobial activity studies. The result revealed that most of the compounds showed moderate to significant antimicrobial activity.